Tuesday, December 15, 2009

St. John’s Wort and Chaste Tree Combination for PMS Symptoms in Peri-menopausal Women by Dr Tori Hudson

The objective of this study was to evaluate the effectiveness of a combination of St. John’s wort and chaste tree berry in the treatment of PMS-like symptoms in peri-menopausal women. This clinical trial was conducted over 16 weeks and information was collected at 4 week intervals rating PMS scores in peri-menopausal women who were experiencing irregular menses.

The daily dose of herbal products given were 3 tablets containing 5400 mg of St. John’s wort standardized to contain 990 mcg hypericin, 9 mg hyperforin and 18 mg flavonoid glycosides. The daily dose of chaste tree berry was one tablet of an extract equivalent to 1000 mg of dry fruit.
This was not a standardized extract. There was a matching placebo group. Participants recorded the severity of their PMS symptoms using the Abraham’s Menstrual Symptom Questionnaire.
The active treatment group was statistically superior to placebo for total PMS-like symptoms as well as subgroups of PMS depression and PMS food cravings.

Commentary: Based on previous research in PMS and chaste tree berry and PMS and St. John’s wort, as well as my clinical experience, it is not surprising that a combination of the two plants would be effective. PMS symptoms are common in regularly menstruating women, and it is also a common phenomenon in peri-menopausal women whose cycle and hormonal regularity is beginning to change. While this study evaluated a small group of women, it does address a significant population of women— those who are peri-menopausal and newly or still, experiencing PMS symptoms.

To purchase NHI's SJW go to http://www.naturalhi.com/Products/StJohnsWort.aspx

For more Blog's from Dr Hudson go to http://drtorihudson.com/


Reference:
Van Die M, Bone K, Burger H, et al. Effects of a combination of Hypericum perforatum and Vitex agnus-castus on PMS-like symptoms in late-perimenopausal women: Findings from a subpopulation analysis. J Alternative and Complementary Medicine 2009;15(9):1045-1048.

Monday, December 7, 2009

High Trterpene Shea Nut Extract Offers a Promising New Approach for Osteoarthritis by Dr Tori Hudson

I have recently been introduced to a new product, shea nut extract, for the treatment of osteoarthritis. Shea nuts have been used in food and Traditional African Medicine for generations, in West Africa in particular. A Danish company has developed a method to greatly concentrate and enhance the triterpenes found in shea nut, yielding a 70% triterpene extract. This high triterpene shea nut extract was allowed into the US in 2004, by the FDA and designated as a new dietary ingredient.

My interest in this product is spurred on by the multiple mechanisms in which these triterpenes seem to impact the joint: regulating cytokines, reducing TNF-a, IL-6, reducing osteocalcin, improving circulation of the joint matrix, slowing inflammatory bone loss, reducing cartilage destruction and restoring collagen.

In one randomized placebo controlled trial, 117 patients with radiographic and clinical evidence of osteoarthritis of the knee or hip were given shea nut extract or placebo for 15 weeks.[1] TNF-alpha reduced 17.9% overall and 23.9% in the group with elevated levels. IL-6 fell by 30.9%; C-reactive protein reduced by 20.6%; CTX-II, a cartilage marker fell by 28.7% in patients with elevated levels vs. an increase in placebo of 17.6%; and osteocalcin reduced by 9.2% in the elevated group indicating bone repair mechanisms.

Animal studies are also being conducted by the manufacturers of high triterpene shea nut extract showing comparable anti-inflammatory effects of ibuprofen but no adverse effects as are often seen in ibuprofen. Other studies are in development and I look forward to those publications.

I have surveyed some retailers and consumers in the natural products market who have been aware of and using high triterpene shea nut extract for several months and been pleased to hear of the consistent anecdotal, yet positive reports. For practitioners, shea nut extract yielding 70% triterpenes is available as BSP 201. I look forward to increasing my own clinical usage of this product and hope to see the same positive results in my patients. With its multiple mechanisms of actions, early research, and anecdotal reports, shea nut extract leaves me optimistic.

For more blogs by Dr Hudson go to http://drtorihudson.com/bone-health/high-triterpene-shea-nut-extract-offers-a-promising-new-approach/


Reference:
[1] Cheras PA, Myers SP, Outerbridge K, & Nielsen G. Randomised Placebo Controlled Trial on the Safety and Efficacy of BSP-201 in Osteoarthritis. Australian Centre for Complementary Medicine Education and Research (ACCMER). Sept. 4, 2007

Tuesday, November 17, 2009

St. John's Wort and Perimenopause by Dr Tori Hudson

This double-blind, randomized clinical trial, studied the effect of Hypericum perforatum extract (St. John’s wort extract) compared with placebo, on symptoms and quality of life of 47 symptomatic perimenopausal women aged 40 to 65 with three or more hot flashes per day. Women were randomly assigned to receive a St. John’s wort extract (900 mg three times per day) or placebo. The women used a daily diary to record hot flash severity and frequency during the week before the study group selection process and again for a week before the end of the three month follow-up. The Menopause-Specific Quality of Life questionnaire was also used.

RESULTS: After 12 weeks of treatment, a non-significant difference in favor of the St. John’s wort group was observed in the daily hot flash frequency and the hot flash score. However, after those three months of treatment, women in the St. John’s wort group reported significantly better quality of life scores, and significantly fewer sleep problems compared to placebo.

Commentary: St. Johns wort research is expanding into the realm of use for perimenopause and menopause symptoms. Other recent studies have reported improvement in psychological, well-being and quality of life in symptomatic perimenopausal and menopausal women. In the current study, while not especially helpful for hot flashes, there was an improvement in quality of life scores and sleep problems. I commonly use St. Johns wort with black cohosh for women with hot flashes and mood issues during perimenopause and menopause. The research on each and even two studies using the combination of the two reveal that these two plants in combination are a premium option for perimenopausal and menopausal women with some of the most common of symptoms.

For more information on St. John's Wort http://www.naturalhi.com/Products/StJohnsWort.aspx

For more blogs, information and events with Dr Hudson preseting please go to http://drtorihudson.com/

Reference
Al-Akoum M, Maunsell E, Verreault R, Provencher L, Otis H, Dodin S. Effects of Hypericum perforatum (St. John’s wort) on hot flashes and quality of life in perimenopausal women: a randomized pilot trial. Menopause. 2009 Mar-Apr;16(2):307-14

Sunday, November 1, 2009

The 2009 H1N1 Influenza — A Greater Understanding by Dr Christina Youngren

A new strain of the H1N1 influenza virus was first detected in the United States this past April. By June, the World Health Organization indicated that a pandemic of 2009 H1N1 flu was underway. Like most viruses, it is transmitted from person to person. It is spread through the air by a cough or sneeze, creating respiratory droplets that contain the virus and gets into the body through the eyes, nose, and mouth. More recently the H1N1 vaccination was made available to the public. Vaccinations have been a part of public health since the late 18th Century and have proven to be a valuable part of medicine at controlling pandemic diseases. Unfortunately with the CDC moving swiftly to prevent spread of the H1N1 virus along with the insurmountable hype on whether an individual should get the H1N1 vaccine or not, many questions still remain unanswered.

Currently the newly available vaccination is recommended for:
− Pregnant women
− Health care and emergency workers
– those in the “front lines”
− Caregivers and household contacts of children younger than 6 months
− Anyone from 6 months to 24 years of age
− Anyone younger than 65 with certain chronic medical conditions or a weakened immune system

The non-live injectable is recommended for the groups below over the live inhalable mist:
− Healthy young people from birth through age 24
− Pregnant women
− Adults 25 to 64 who have underlying medical conditions.

As more vaccine becomes available, these groups will be recommended immunization:
− Healthy 25 through 64 year olds
− Adults 65 years and older

What You Should Know

The first available injectable vaccination contains thimerosal (mercury) as a preservative and squalene as an adjuvant, which helps to make the vaccine more potent and ensure efficacy. In my medical practice, I do not recommend vaccines that use thimerosal for anyone, but especially for children less than 2 years of age. The CDC recommends that children ages 6 months through 9 years receive two doses of the non-live H1N1 vaccine. For infants that are on the standard immunization schedule, this adds up to almost 16 vaccinations by 9 months of age. My concern is not only the high number of vaccinations, but many reports have shown that use of squalene as an adjuvant in vaccinations suggest an association between the vaccination and various autoimmune diseases.

According to the CDC, the 2009 H1N1 flu has caused greater disease burden in people younger than 25 years of age than older individuals. As a naturopathic doctor, I am inclined to think that the virus plagues unsuspecting, middle school through college-aged students putting them most at risk because of their diet and lifestyle. Typically their diets are made up of fast food, soda pop, snacks and quick meals that are packaged or processed to be easily prepared. They have social agendas and busy lifestyles that can affect sleep patterns, resulting in less hours of good quality sleep. Demanding school/class schedules can leave them stressed and depleted. Finally, less than perfect hygiene such as sharing drinking/water glasses, eating utensils, make up, lip balm, kissing, constant close contact, and poor hand washing or improper containment of their coughs and sneeze, all of which contribute to greater susceptibility.

Side Effects of the Vaccination
The H1N1 non-live vaccination insert warns that it can cause:
− Local injection site reactions (pain, tenderness, redness, swelling, warmth, ecchymosis, induration)
− Headache
− Fatigue
− Malaise
− Myalgia
− Chills
− Fever
− Sore throat
More adverse reactions include anaphylactic shock, Guillain-Barré syndrome, vasculitis, immune system disorders, paralysis, dyspnea and death.

Specific Populations: Pregnant and Lactating Women, Children, and Elderly

With the recent development of the new H1N1 vaccination, it probably goes with out saying that adequate research has yet to be completed. This is probably the most frightening aspect affecting many parents decision on whether to vaccinate their child or not. According to the manufacturer, reproductive studies have not been conducted. This proposes the greatest threat to pregnant and lactating women and children (< 4 years), yet according to the CDC recommendations, 2 out of 3 of those groups are considered most at risk and should be the first to receive the vaccination. The vaccination is labeled Pregnancy C, which typically means that animal studies have shown to have an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks. As already mentioned, the 2009 H1N1 vaccination is very new and has yet to be tested on animals. The manufacturer insert further states that safety and effectiveness in pregnancy, fetus, and pediatric subjects have not been established.
A recent Consumer Reports survey found that 50% of parents are delaying the vaccination and 43% of parents are not concerned about their children contracting the virus. It also found that 14% of parents have ruled out giving their children the vaccination altogether compared to 35% who would immunize.

Prevention – A Possible Treatment

What are your options? Do you feel empowered by the information provided by your healthcare provider? As of right now, the risks of the H1N1 vaccination have not been clearly delineated and yet both the CDC and FDA believe that the benefits of vaccination will far outweigh the risks. The groups above or anyone who is not a candidate due to potential allergic reaction, has Guillain-Barré syndrome, autoimmune conditions or individuals who do not want to be vaccinated, may decrease their risk if they are properly educated on how to prevent spread through proper hygiene, dietary and lifestyle changes. Individuals who have a known high risk (asthma, severe allergies or serious health complications) should immediately begin working closely with their doctor to gain a full understanding of the H1N1 flu vaccine and ways to help them boost their immune systems.

Preventive Treatment Protocol: Diet, Lifestyle and Nutritional Support

Diet

Building a stronger immune system requires a diet rich in vegetables, fruits, whole grains, nuts, legumes, and seeds and avoiding refined sugar, caffeine, white flour, and highly refined or processed foods, is a great start. It has been well documented that sugar has an impact on the immunity where avoidance can help boost immunity and intake of a single sugary treat can actually depress the immune system for up to 48 hours after intake. Caffeine and the typical forms that it is consumed, coffee and soda pop, deplete the body of essential vitamins and minerals and also causes dehydration. Processed and refined foods are void of naturally containing nutrients and typically contain harmful toxins that leave the immune system less adept to fight outside invaders such as a bacteria or virus. On the other hand, a whole food diet with plenty of organic vegetables and fruits (see dirty dozen), whole grains, nuts, legumes, seeds and even some teas, provides your body with plenty of phytonutrients or phytochemicals, which the body uses to help build a healthy immune system.

Lifestyle Factors: Decrease Stress and Exercise

Stress can play a major contributing factor in depressed immunity. Decreasing life’s stressors will contribute to improved immune function. Helpful techniques include guided imagery, which typically involves visualizing serene images or breathing techniques that focuses on relaxation. You can also try yoga or Qigong, which combine both mental and physical exercise, and can help heal the mind and the body. Regular exercise is known to protect and enhance the immune response. Moderate physical activity of 30 minutes support immunity, which results in fewer days of sickness with the common cold and other upper respiratory tract infections.
Nutritional SupportVitamin D3 [1,25(OH) 2] is a steroid hormone and has profound effects on human immunity by acting as an immune system modulator. It stimulates the expression of potent anti-microbial peptides such as neutrophils, monocytes, and natural killer cells. It works directly the epithelial cells lining the respiratory tract, which play a major role in protecting the lungs from infection.

You can also get Vitamin D from the sun. If you live where you can get 20 minutes of unprotected sun exposure a day that should suffice. Individuals living in sunny climates should get Vitamin D test done to know their exact levels, as a recent survey done on Arizona residents found that almost 90% were Vitamin D deficient. Use of sunscreens, protective clothing, and darker skin pigment block the sun and decrease Vitamin D levels.− After 2 months on Vitamin D therapy, a 25(OH) D blood test should be performed by your doctor

Colostrum with IgG serums: most common form found in body and new mom’s breast milk. Bovine colostrum delivers growth, nutrient, and immune factors to the offspring. It contains immunoglobulins or antibodies that are released into the bloodstream in response to infections and may help improve immune system functions. It has also been shown to be effective against certain types of bacterial and viral infections.

Vitamin C: As an antioxidant it helps to prevent and treat the common cold and other viral infections, bronchitis, and improves immune function. T-lymphocyte activity, phagocyte function, leukocyte mobility, and possibly antibody and interferon production seem to be increased by Vitamin C intake. Vitamin C is labile, and the amount in foods can decrease significantly with cooking and storage.

Probiotics: Lactobacillus is used to prevent respiratory infections in children attending day-care centers. A study found that children who took a probiotic with lactobacillus acidophilus and bifidus reduced their incidence of fever, colds, and cough.

Zinc: Supports neutrophil, natural killer cell, and T-lymphocyte functionality all of which aid in immune system support.

Use To Possibly Prevent or Treat The symptoms of Cold and Flu:
Oscillococcinum: Symptoms of cold and flu, chills and fever, body aches and fatigue.
GUNA Flu: Symptoms of cold and flu, chills and fever, body aches and fatigue.
***Remember there is no “magic pill” or antidote***

Transference: Bodily fluids and Entry of Virus
− Eyes
− Nose
− Mouth
− Touching the nose, mouth or a surface/object (door knob, counter top, bus seat) that someone who is infected has touched and then rubbing the eyes or nose or mouth.

H1N1 Flu infection cannot be transmitted by
− Eating pork or pork products
− Not controlled or prevented by killing unaffected animal

Lifestyle and Hygienic Recommendations:
− Wash hands with soap and warm water
— You should sing the “ABC’s” as a guideline for length of time, which equivalent to 20 seconds− Contain your cough or sneeze by using your hand or handkerchief
− Designate one caregiver to the individual who is sick

Signs and Symptoms of the H1N1 Flu Infection
A cough and high fever (over 100ºF) that come on suddenly. Should be tested with a nasal or throat swab. Additional symptoms include:
−Sore throat
− Body aches
− Headache
− Chills and fatigue
− Diarrhea and vomiting (less common)
− The incubation period for the flu is normally 24-48 hours, and the contagious period lasts for seven days after the onset of symptoms

If you suspect that you or a loved one is ill with H1N1 Flu Infection:
− Stay at home: the CDC recommends that you stay home for at least 24 hours after your free of fever
− High Fever: Seek medical attention if a child’s fever remains at or above 103 degrees for greater than 1 day; adults greater than 2 days.
− Consult with everyone you have been around and check on their status: this will be key to reducing further spread

By Dr Christina Youngren http://www.drchristinayoungren.com/blog/

References:
Bernstein, J., al. Depression of Lymphocyte Transformation Following Oral Glucose Ingestion. American Journal of Clinical Nutrition.1997;30:613
Cannell MD, John. http://www.vitamindcouncil.org/newsletter/h1n1-flu-and-vitamin-d.shtml
Influenza A (H1N1) 2009 Monovalent Vaccine Manufactured by Novartis Vaccines and Diagnostics Ltd. Suspension for Intramuscular Injection
Kuroda Y, Nacionales DC, Akaogi J, Reeves WH, Satoh M. Autoimmunity induced by adjuvant hydrocarbon oil components of vaccine. Biomed Pharmacother. 2004 Jun;58(5):325-37.
Kenney RT, Edelman R. Expert Rev Vaccines. 2003 Apr;2(2):167-88.
Leyer GJ, Li S, Mubasher ME, Reifer C, Ouwehand AC. Probiotic effects on cold and influenza-like symptom incidence and duration in children.
Matthews, C.E., I.S. Ockene, P.S. Freedson, M.C. Rosal, J.R. Herbert, and P.A.Merriam. 2000. Physical activity and risk of upper-respiratory tract infection
Psychopharmacology: Categorizing the Safety of Medications During Pregnancy and Lactation. Journal of Psychosocial Nursing and Mental Health Services Vol. 47 No. 4 April 2009.
Sanchez, A., et al. Role of Sugars in Human Neutrophilic Phagocytosis, American Journal of Clinical Nutrition. Nov 1973;261:1180_1184.

Friday, October 30, 2009

Vitamin D deficiency may be associated with poor outcomes in breast cancer patients by Dr Tori Hudson

This prospective study of 512 women with early breast cancer evaluated the role of serum vitamin D levels as a potential factor influencing breast cancer prognosis.

The average age was 50 and the average vitamin D levels was 58.1 nmol/L. Vitamin D levels were deficient (<50> 72 nmol/L in 123 women. The average follow-up was 11.6 years with 116 women having distant recurrences and 106 women who died. Vitamin D levels were significantly lower in women with high grade tumors. Those women with vitamin D deficiency had an increased risk of distant recurrence and of dying, compared with those women who had sufficient serum vitamin D levels.

Commentary: This study is one more reason to test vitamin D levels- I would recommend it for all current or past breast cancer patients. In terms of using vitamin D levels to determine the initial risk for breast cancer, the evidence has been mixed, with some showing an association between latitude and risk of breast cancer, some showing an inverse relationship between vitamin D intake and breast density (a strong risk factor for breast cancer), but other studies showing vitamin D intake or blood levels of vitamin D inconsistently related to risk/incidence.
There have been some other attempts to use vitamin D levels as a prognostic indicator for breast cancer and mortality. Low vitamin D levels have been associated with increased breast cancer mortality and have also been shown to be significantly lower in women with locally advanced or metastatic disease compared with those women who have early breast cancers. Taking a vitamin D supplement to increase blood levels of vitamin D is one of the least expensive, safe strategies to reduce the risk of recurrence of breast cancer, as stated in this current study. For the rest of us… the research is full of good news about vitamin D and our health with studies demonstrating that higher blood levels of vitamin D is associated with lower rates of heart disease, ovarian cancer, multiple sclerosis, osteoarthritis and rheumatoid arthritis, bacterial vaginosis, and as mentioned, breast cancer.

It should be noted that the current studies, and in fact many studies, report vitamin D levels in the units of nmol/L. Other studies report ng/ml. This is a very important difference. It is important to compare one’s lab unit results for vitamin D levels with the proper target number and unit used. For reference, 75 nmol/L is equal to 30 ng/mL. In the current study, those women who had a vitamin D deficiency and reported as < 50 nmol/L would be equivalent to
< 20 ng/ml.

References
Goodwin P, Ennis M, Pritchard K, et al. Prognostic effects of 25hydroxyvitamin D levels in early breast cancer. J Clinical Oncology 2009;27(23): 3757-3763

For more of Dr Hudson's posts go to http://drtorihudson.com/

Wednesday, April 8, 2009

Your Health & the Healthcare Industry

The terms integrated and holistic health now include so many different therapies and health modalities that many consumers, patients and doctors alike are getting lost in the maze, or overwhelmed with choices. This Blog has been written to offer information, guidance and opinions on all therapies based on experience, research and inside knowledge. It will also offer advice and information on specific key health concerns such as fertility, cancer, menopause, osteoporosis, PMS, sleep disorders, heart disease, how to lose weight healthily, nutrition and the list goes on.

Let me start with the premise that I believe that your health should be founded on addressing four key areas: Diet & Nutrition, Exercise & Movement, Environment & Lifestyle and Empowerment (this includes emotional and spiritual health as well as attitude to your health and knowledge). This foundation should be aligned with treatment or wellness therapies that are in line your own person health time line, your own belief system and combined to form your own person health plan.

Your own personal health time line relates to your personal health situation at that time. For example if your liver has failed and you need a transplant, dialysis is only going to do so much and milk thistle isn’t an option. However if you aren’t at this critical stage on your own health time line there are a variety of therapies whether they are allopathic or complementary that offer you solutions. Your healthcare choices are very much a personal decision and this Blog will simply put forward options, information and advice based on knowledge and a vast amount of experience by our blogging team. This Blog will also comment on events and realities in the health and natural products industry which being on the “inside” gives us access to and that I think it is important to make known to the public.

The natural products industry we believe is no different to every other industry and is focused on making money. Making money isn’t a bad thing as books like Sacred Commerce discuss. If business creates a win/win/win result for the consumer, employee, company, community, environment and everyone involved. It is when companies, whether consciously or unconsciously, create a win/lose scenarios that business becomes a negative relationship. However fortunately there are a number of individuals and companies that do try to make a difference, have the best quality products and focus on win/win/win results.

One of my personal business philosophy’s is that if you put people before profit, profit will come.

Please leave me your comments and questions and our team will always get back to you.

Regards,

James