St. John’s Wort and Chaste Tree Combination for PMS Symptoms in Peri-menopausal Women by Dr Tori Hudson

The objective of this study was to evaluate the effectiveness of a combination of St. John’s wort and chaste tree berry in the treatment of PMS-like symptoms in peri-menopausal women. This clinical trial was conducted over 16 weeks and information was collected at 4 week intervals rating PMS scores in peri-menopausal women who were experiencing irregular menses.

The daily dose of herbal products given were 3 tablets containing 5400 mg of St. John’s wort standardized to contain 990 mcg hypericin, 9 mg hyperforin and 18 mg flavonoid glycosides. The daily dose of chaste tree berry was one tablet of an extract equivalent to 1000 mg of dry fruit.
This was not a standardized extract. There was a matching placebo group. Participants recorded the severity of their PMS symptoms using the Abraham’s Menstrual Symptom Questionnaire.
The active treatment group was statistically superior to placebo for total PMS-like symptoms as well as subgroups of PMS depression and PMS food cravings.

Commentary: Based on previous research in PMS and chaste tree berry and PMS and St. John’s wort, as well as my clinical experience, it is not surprising that a combination of the two plants would be effective. PMS symptoms are common in regularly menstruating women, and it is also a common phenomenon in peri-menopausal women whose cycle and hormonal regularity is beginning to change. While this study evaluated a small group of women, it does address a significant population of women— those who are peri-menopausal and newly or still, experiencing PMS symptoms.

To purchase NHI's SJW go to http://www.naturalhi.com/Products/StJohnsWort.aspx

For more Blog's from Dr Hudson go to http://drtorihudson.com/


Reference:
Van Die M, Bone K, Burger H, et al. Effects of a combination of Hypericum perforatum and Vitex agnus-castus on PMS-like symptoms in late-perimenopausal women: Findings from a subpopulation analysis. J Alternative and Complementary Medicine 2009;15(9):1045-1048.

High Trterpene Shea Nut Extract Offers a Promising New Approach for Osteoarthritis by Dr Tori Hudson

I have recently been introduced to a new product, shea nut extract, for the treatment of osteoarthritis. Shea nuts have been used in food and Traditional African Medicine for generations, in West Africa in particular. A Danish company has developed a method to greatly concentrate and enhance the triterpenes found in shea nut, yielding a 70% triterpene extract. This high triterpene shea nut extract was allowed into the US in 2004, by the FDA and designated as a new dietary ingredient.

My interest in this product is spurred on by the multiple mechanisms in which these triterpenes seem to impact the joint: regulating cytokines, reducing TNF-a, IL-6, reducing osteocalcin, improving circulation of the joint matrix, slowing inflammatory bone loss, reducing cartilage destruction and restoring collagen.

In one randomized placebo controlled trial, 117 patients with radiographic and clinical evidence of osteoarthritis of the knee or hip were given shea nut extract or placebo for 15 weeks.[1] TNF-alpha reduced 17.9% overall and 23.9% in the group with elevated levels. IL-6 fell by 30.9%; C-reactive protein reduced by 20.6%; CTX-II, a cartilage marker fell by 28.7% in patients with elevated levels vs. an increase in placebo of 17.6%; and osteocalcin reduced by 9.2% in the elevated group indicating bone repair mechanisms.

Animal studies are also being conducted by the manufacturers of high triterpene shea nut extract showing comparable anti-inflammatory effects of ibuprofen but no adverse effects as are often seen in ibuprofen. Other studies are in development and I look forward to those publications.

I have surveyed some retailers and consumers in the natural products market who have been aware of and using high triterpene shea nut extract for several months and been pleased to hear of the consistent anecdotal, yet positive reports. For practitioners, shea nut extract yielding 70% triterpenes is available as BSP 201. I look forward to increasing my own clinical usage of this product and hope to see the same positive results in my patients. With its multiple mechanisms of actions, early research, and anecdotal reports, shea nut extract leaves me optimistic.

For more blogs by Dr Hudson go to http://drtorihudson.com/bone-health/high-triterpene-shea-nut-extract-offers-a-promising-new-approach/


Reference:
[1] Cheras PA, Myers SP, Outerbridge K, & Nielsen G. Randomised Placebo Controlled Trial on the Safety and Efficacy of BSP-201 in Osteoarthritis. Australian Centre for Complementary Medicine Education and Research (ACCMER). Sept. 4, 2007